Complications and survival in COPD patients undergoing lung transplantation

<bold>Introduction and methodology</bold> Lung transplantation is a therapeutic option in patients with advanced and irreversible lung disease. Advanced and irreversible lung disease, with chronic obstructive pulmonary disease (COPD) being the first indication for lung transplantation. Retrospective observational study of patients referred to the referral lung transplant unit from a monographic COPD consultation at the Hospital Universitario Virgen Macarena between January 1, 2013 and November 30, 2023. <bold>Results:</bold> 24 out of 65 patients who were referred for lung transplant evaluation, were transplanted 37%. Among the transplant recipients, there was a predominance of males (70.8%). Some type of medium/long-term complication secondary to lung transplantation was reported in 15 patients (62.5%). The most frequent complication was chronic kidney disease (CKD) secondary to treatment with calcineurin inhibitors in 29% of cases (5 patients), followed by infectious complications in 23.5%, as well as the appearance of tumors in 23.5% of cases, 18% (3 patients) presented chronic graft dysfunction and 6% (1 patient) were diagnosed with gastroesophageal reflux disease. Median survival after transplantation was 33 months (11-65, 95%CI). Mortality in transplanted patients was 45.8% (n=11). Among the causes of mortality were infectious (36%), neoplasms (27%) and perioperative complications. <bold>Conclusion:</bold> - More and more patients are being referred to transplantation units. - Mortality in our series is considerable, probably related to the impact of the pandemic on these patients. of the pandemic in these patients. - Medium/long-term complications in transplant patients are relatively frequent. frequent.