Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay
This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.
Authors
- Jairo Méndez‐Rico
- Felipe Campos de Melo Iani (ORCID: https://orcid.org/0000-0002-3629-8529)
- Noelia Morel (ORCID: https://orcid.org/0009-0002-2792-0627)
- Viviana Ramas
- Leticia Cóppola
- Ana I. Bento
- Héctor Chiparelli (ORCID: https://orcid.org/0000-0002-8713-1067)
- Mauricio Teixeira Lima (ORCID: https://orcid.org/0000-0002-0830-3909)
- Alexander Rosewell (ORCID: https://orcid.org/0000-0002-5437-9920)
- Emerson Castro (ORCID: https://orcid.org/0000-0002-3210-7342)
- Luíz Carlos Júnior Alcântara (ORCID: https://orcid.org/0000-0002-6769-9931)
- Analía Burgueño
- Marta Giovanetti (ORCID: https://orcid.org/0000-0002-5849-7326)
- Vagner Fonseca (ORCID: https://orcid.org/0000-0001-5521-6448)
- José Lourenço (ORCID: https://orcid.org/0000-0002-9318-2581)
- Leticia Franco (ORCID: https://orcid.org/0000-0002-4065-4979)
- Natália Rocha Guimarães (ORCID: https://orcid.org/0000-0002-9859-5895)
- Victoria Bormida
- María Noel Cortinas
Institutions
- Rockefeller Foundation (US)
- Universidade do Estado da Bahia (BR)
- University of Lisbon (PT)
- Università Campus Bio-Medico (IT)
- Universidade Católica Portuguesa (PT)
- World Health Organization Regional Office for the Americas (US)
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais (BR)
- Ezequiel Dias Foundation (BR)
- Hospital São Vicente de Paulo (BR)
- Pan American Health Organization (Brasil) (BR)
- Climate Foundation (US)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e39246
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Institutes of Health