The measurement of immunosuppressive drugs by mass spectrometry and immunoassay in a South African transplant setting
The cyclosporine ECLIA yielded results comparable to LC-MS/MS while poorly comparable results were obtained for everolimus and sirolimus, which may be explained by ISD metabolite cross-reactivity, amongst other factors. The poor comparability, although not unique, is noteworthy and the clinical consequences of these differences require further investigation.
Authors
- A.J.C. Strydom
- Sean Currin (ORCID: https://orcid.org/0000-0003-2487-6763)
- Doreen Jacob (ORCID: https://orcid.org/0000-0003-2835-7303)
- Taryn Pillay
- Refeletse Malahlela
Institutions
- National Health Laboratory Service (ZA)
- University of the Witwatersrand (ZA)
Publication Details
- Journal
- Practical Laboratory Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.plabm.2024.e00440
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Roche
- National Health Laboratory Service