Phthalates are detected in the follicular fluid of adolescents and oocyte donors with associated changes in the cumulus cell transcriptome
Adolescents undergoing fertility preservation cycles demonstrate higher levels of phthalate metabolites in their FF than oocyte donors. Higher phthalate levels are associated with alterations in cumulus cells transcriptome in adolescents. The phthalate metabolite levels in FF are associated with higher antral follicle count levels in oocyte donors.
Authors
- Anna Kleinhans
- Mary J. Laws (ORCID: https://orcid.org/0000-0001-5140-488X)
- Dilan Gokyer (ORCID: https://orcid.org/0000-0001-9017-3260)
- Jodi A. Flaws (ORCID: https://orcid.org/0000-0001-5579-9268)
- Elnur Babayev (ORCID: https://orcid.org/0000-0003-2948-6342)
- Joan K. Riley
Institutions
- Northwestern University (US)
- University of Illinois Urbana-Champaign (US)
- Fertility Centers of Illinois (US)
- Northwestern Medicine (US)
Publication Details
- Journal
- F&S Science
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.xfss.2024.10.009
- Citations
- 1
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- National Institute of Child Health and Human Development