Major depressive disorder is associated with mitochondrial <i>ND6</i> T14502C mutation in two Han Chinese families
Identifying the T14502C mutation in two individuals with no genetic relation who exhibit symptoms of depression provides compelling evidence that this mutation may be implicated in MDD development. Nonetheless, the two Chinese pedigrees that carried the T14502C mutation did not exhibit any functionally significant mutations in their mtDNA. Therefore, the phenotypic expression of the T14502C mutation related to MDD may be influenced by the nuclear modifier gene(s) or environmental factors.
Authors
- Pan Jing
- Ming Liang (ORCID: https://orcid.org/0000-0002-2723-9041)
- Xuewen Xu (ORCID: https://orcid.org/0000-0002-0269-9308)
- Ting Xu (ORCID: https://orcid.org/0000-0003-1590-9025)
- Ling-Jiang Liu
- Tingting Xia (ORCID: https://orcid.org/0000-0001-5145-9506)
- Xiaobin Zhang (ORCID: https://orcid.org/0000-0002-0577-5951)
- Bi-Hua Yu
- Haihang Yu
- Tingting Wu
Institutions
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
- Ningbo Kangning Hospital (CN)
- Xiangshan County First People's Hospital (CN)
Publication Details
- Journal
- World Journal of Psychiatry
- Published
- 2024-11-07
- DOI
- https://doi.org/10.5498/wjp.v14.i11.1746
- Citations
- 2
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Government of Jiangsu Province