Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth
Vaccine administration earlier in the approved 32 to 36 week window (at least 5 weeks prior to delivery) results in the highest transplacental transfer of maternal antibodies to the neonate. These results should inform the counseling of pregnant individuals on optimal vaccination timing.
Authors
- Andrea G. Edlow (ORCID: https://orcid.org/0000-0003-2915-5949)
- Zeynep Bahadır (ORCID: https://orcid.org/0000-0002-7293-8060)
- Lael M. Yonker (ORCID: https://orcid.org/0000-0003-1711-8227)
- Lydia L. Shook (ORCID: https://orcid.org/0000-0002-5859-8610)
- Carol R. Bradford (ORCID: https://orcid.org/0000-0002-2768-4532)
- Antônio Nélson
- Michal A. Elovitz (ORCID: https://orcid.org/0000-0001-7554-7180)
- S.R. Permar
- Liza Konnikova (ORCID: https://orcid.org/0000-0003-4804-5497)
- Emily Gilbert
- Douglas A. Lauffenburger (ORCID: https://orcid.org/0000-0002-0050-989X)
- Andrew Pekosz (ORCID: https://orcid.org/0000-0003-3248-1761)
- Steffen Klein (ORCID: https://orcid.org/0000-0002-8046-0474)
- Maria Dennis
- Olyvia Jasset
- Paola Andrea Lopez Zapana
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-1363-6708)
- Alexa H Silfen
- Rachel V Yinger
- Caroline Bald
Institutions
- Johns Hopkins University (US)
- Cornell University (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Reproductive Science Center (US)
- Weill Cornell Medicine (US)
- Massachusetts Institute of Technology (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- American Journal of Obstetrics and Gynecology
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1016/j.ajog.2024.10.053
- Citations
- 17
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 6.57
Funders
- Massachusetts General Hospital
- United States - Israel Binational Science Foundation
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development