The antimicrobial properties of exogenous copper in human synovial fluid against <i>Staphylococcus aureus</i>
SF has antimicrobial properties against <i>S. aureus</i>, and UAMS-1 was more sensitive than USA300 WT. Adding 10 µM of copper was highly toxic, confirming its bactericidal effect. We found CopAZB proteins to be involved in copper effluxion by demonstrating the high sensitivity of mutant strains to lower copper concentrations. Thus, we propose CopAZB proteins as potential targets and use exogenous copper as a treatment alternative against <i>S. aureus</i>.
Authors
- David E. Heinrichs (ORCID: https://orcid.org/0000-0002-7217-2456)
- Edward M. Vasarhelyi (ORCID: https://orcid.org/0000-0001-9942-9605)
- David Watson (ORCID: https://orcid.org/0000-0002-6191-2332)
- Fernando Diaz (ORCID: https://orcid.org/0000-0002-7830-2207)
Institutions
- Western University (CA)
- Queen's University (CA)
- London Health Sciences Centre (CA)
- Kingston Health Sciences Centre (CA)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2024-11-07
- DOI
- https://doi.org/10.1302/2046-3758.1311.bjr-2024-0148.r1
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research