The effect of elimination and irrigation hyperosmolar solution of xylitol therapy usage in allergic rhinitis patients

The main goal of the study was to evaluate the effectiveness of using a hyperosmolar solution of xylitol as an elimination and irrigation therapy for allergic rhinitis. 21 patients with persistent allergic rhinitis, with sensitization to house dust mites, confirmed by SPT or specific IgE, were selected and randomized into 3 groups - 1st using only elimination according to the doctor's recommendations, 2nd additionally used nasal irrigation and 3rd used symptomatic therapy in addition. Age ranged from 18 to 42 years, average age 32.3 years (95% CI: 36.1, 28.5). All patients were interviewed according to the TNSS questionnaire at the initial visit at two control points - on the 5th and 10th day of therapy. The severity of nasal symptoms according to the TNSS at the initial visit was comparable (7.2, 7.4 and 7.2 points, respectively), but at the first control point the severity of symptoms of the first and second groups was statistically significantly different (6.1 and 5.3 points , respectively), and in the third group it decreased by almost two times (3.2 points). At the third control point (on the 10th day), the severity of the symptoms of the first and second groups had a tendency to a slight further decrease (5.8 and 5.0 points, respectively), and in the third group it significantly decreased from the initial level (2.9 points). Rhinomanometry demonstrated the highest effectiveness of combined therapy. Thus, hyperosmolar solution of xylitol can be used in the elimination therapy of allergic rhinitis, with irrigation and anti-edema effect. In most cases, avoidance measures are not enough for the treatment of allergic rhinitis with sensitivity to house dust mites.