Causal Links Between Diabetes and Chronic Obstructive Pulmonary Disease: A Bidirectional Two-Sample Mendelian Randomization Study

<bold>Aims:</bold> COPD Patients often experience multiple comorbidities such as diabetes. The COPD-diabetes association is documented epidemiologically, however, the causality between them has not been established yet. <bold>Methods:</bold> We conducted a bidirectional two-sample Mendelian randomization analysis to evaluate the causal links between T1D/T2D and COPD by using GWAS data from European and Asian populations, through comprehensive discovery and validation processes (Fig. 1). The causal effect of diabetes on COPD-related outcomes was also assessed. <bold>Results:</bold> A relationship between T2D and an increased odds of COPD in European population was suggested (Fig. 2). No robust evidence of causal correlation was found between diabetes and the risk of COPD in Asian ancestry. Besides, the genetically determined T1D was identified as a risk factor for the incidence of infections in COPD patients in European-specific population. <bold>Conclusions:</bold> This study indicated a potential causal link between diabetes and COPD in European individuals. Further validations are needed to promote the management of multi-diseased COPD patients. <fig><object-id>erj;64/suppl_68/PA4864/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> Fig. 1 <fig><object-id>erj;64/suppl_68/PA4864/F2</object-id><object-id>F2</object-id><object-id>F2</object-id><graphic></graphic></fig> Fig. 2