Health-related quality of life (HRQoL) in depression defined by clinicians and patients in severe asthma. Data from SHARP CRC

<bold>Background:</bold> Depression is more common in severe asthma than in the general population and is associated with poorer outcomes. <bold>Aim:</bold> To describe HRQoL and asthma control in patients with and without a recorded diagnosis of depression by their GP or other clinician and indicated by the Patient Health Questionnaire-2 (PHQ-2). <bold>Method:</bold> Real-word data from adults in the Severe Heterogeneous Asthma Research Collaboration Patient-centered (SHARP) registry included the Severe Asthma Questionnaire (SAQ), SAQ-global and Asthma Control Questionnaire-6 (ACQ) collected via PatientCoach app. PHQ-2 scores of ≥3 indicate depression. <bold>Results:</bold> 216 participants provided data. All questionnaire scores were significantly (p <0.01) worse for those with a clinical record of depression and a PHQ2 ≥3 compared to those with no clinical record of depression and a PHQ-2 ≤2. SAQ and SAQ-global but not ACQ scores were significantly (p <0.05) worse for patients with no clinical record of depression and a PHQ-2 ≥3 compared to those with a clinical record of depression and PHQ-2 ≤2 (Table 1). Age and gender did not differ significantly between groups. <bold>Conclusion:</bold> These data highlight the importance of patients own evaluations of depression, and its impact on HRQoL. Table 1. Questionnaire scores (n) and <italic>SD</italic> for clinical record and/or patient indicated depression. <table-wrap><object-id>erj;64/suppl_68/PA3231/TB1</object-id><object-id>T1</object-id><object-id>TB1</object-id><table><colgroup><col></col><col></col><col></col><col></col><col></col></colgroup><tbody><tr><td></td><td>No clinical record of depression</td><td>Clinical record of depression</td></tr><tr><td></td><td>PHQ2 ≤2</td><td>PHQ2 ≥3</td><td>PHQ2 ≤2</td><td>PHQ2 ≥3</td></tr><tr><td>SAQ (1-7)</td><td>5.77 <break></break>(131) <break></break><italic>1.74</italic></td><td>3.61 <break></break>(37) <break></break><italic>1.51</italic></td><td>4.99 <break></break>(13) <break></break><italic>1.57</italic></td><td>2.84 <break></break>(14) <break></break><italic>1.89</italic></td></tr><tr><td>SAQ-global (0-100)</td><td>72.99 <break></break>(131) <break></break><italic>19.04</italic></td><td>45.14 <break></break>(37) <break></break><italic>21.29</italic></td><td>60.38 <break></break>(13) <break></break><italic>21.93</italic></td><td>39.29 <break></break>(14) <break></break><italic>21.02</italic></td></tr><tr><td>ACQ (6-0)</td><td>1.21 <break></break>(150) <break></break><italic>1.10</italic></td><td>2.57 <break></break>(37) <break></break><italic>1.46</italic></td><td>1.95 <break></break>(14) <break></break><italic>1.34</italic></td><td>3.22 <break></break>(15) <break></break><italic>1.33</italic></td></tr></tbody></table></table-wrap>