Psychometric properties of the PROMIS® measures in a pediatric asthma population in the Netherlands

<bold>Objective:</bold> In pediatric asthma care, currently used disease-specific legacy Patient Reported Outcome Measures (PROMs) are considered burdensome due to their length and irrelevant questions. PROMIS® measures could solve this problem. This study aims to investigate the psychometric properties of PROMIS measures in children with asthma. <bold>Methods:</bold> Dutch children (8-17 yrs) with asthma (GINA step 2-5) will complete 9 pediatric PROMIS measures as short-form or computerized adaptive test (Asthma Impact, Depressive Symptoms, Anxiety, Fatigue, Peer Relationships, Sleep Disturbance, Mobility, Global Health, Anger) & 3 legacy measures (Asthma Control Test, Pediatric Asthma QoL Questionnaire, PedsQLTM - Asthma module). We will investigate: 1) convergent validity by comparing PROMIS measures T-scores to scores of legacy measures using Pearson’s r, 2) reliability using Cronbach’s alpha and standard error of theta (SE(θ)), and 3) efficiency by calculating performance of the PROMIS and legacy measures relative to the number of items administered. PROMIS mean T-scores will be calculated to provide pediatric asthma reference data. <bold>Expected results:</bold> We aim to include 100 participants. High correlations (r>0.7) between PROMIS Asthma Impact and associated asthma impact subscales of the legacy measures, and good reliability (SE(θ)<0.32) for all PROMIS measures are expected. We expect PROMIS measures to be more efficient than legacy measures in number of items administered, while retaining a reliable measurement. <bold>Conclusions:</bold> If the pediatric PROMIS measures display good psychometric properties, PROMIS can be used in research and clinical care for children with asthma, and thus reduce PROM-related burden.