Heterogeneity of comorbidities captured by European national severe asthma registries in SHARP CRC

<bold>Introduction:</bold> There is growing awareness that comorbidities and multimorbidity impact disease control and quality of life in patients with severe asthma. However, it remains unclear as to how well these conditions are recognised in clinical practice. National severe asthma registries benchmark clinical practice and offer an opportunity to assess how well comorbidities are being considered. <bold>Aim:</bold> We assessed comorbidities collected in 20 European severe asthma registries by studying the Federated Analysis Platform (FAP) of SHARP. <bold>Methods:</bold> The SHARP FAP was used to map comorbidities from 8 European national severe asthma registries in addition to SHARP Central – a harmonised data registry used by 12 countries. <bold>Results:</bold> 48 comorbidities were mapped across the 20 registries. T2-related conditions were best captured with chronic sinusitis and nasal polyposis included in 100% registries, allergic rhinitis 95% and eczema 90%. Several pulmonary (COPD 90%, bronchiectasis 85%, obstructive sleep apnea 75%), extrapulmonary (gastroesophageal reflux 100%, cardiovascular disease 90%) and psychophysiological (depression 85%) were also frequently recorded. Osteoporosis was collected in 85% but other steroid induced pathologies were less well recorded (cataract 70%, diabetes 55%, adrenal insufficiency 40% and glaucoma 25%). <bold>Conclusions:</bold> There is much variability in comorbidity data included in European severe asthma registries. T2 and pulmonary comorbidities are covered well, however the capture of potential steroid induced pathologies is suboptimal, revealing a possible gap in our daily clinical practice which could be improved with harmonisation of the registries in the near future.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa1763
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
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article

Heterogeneity of comorbidities captured by European national severe asthma registries in SHARP CRC

Florin Mihălţan, Piotr Kuna, Ramesh Kurukulaaratchy, Anneke Ten Brinke et al.
Chronic Obstructive Pulmonary Disease (COPD) Research
article

Heterogeneity of comorbidities captured by European national severe asthma registries in SHARP CRC

Florin Mihălţan, Piotr Kuna, Ramesh Kurukulaaratchy, Anneke Ten Brinke, Bilun Gemicioğlu, Sabina Škrgat, Jacob K. Sont, Aruna T. Bansal, Georgio Walter Canonica, Florence Schleich, Betty Frankemölle, Εleftherios Ζervas, Cláudia Loureiro, Zsuzsanna Csoma, ARNAUD AB BOURDIN, Svetlana Sergejeva, Saša Rink, Apostolos Bossios, K Bieksiene, Stephanie Korn, Valentyna Yasinska, Sanja Grle Popović, David Ramos‐Barbón, Sanja Hromiš, Celeste Porsbjerg, Mehar Singh, Louis Renaud, Anna Freeman, Ineta Grisle
article en

Abstract

<bold>Introduction:</bold> There is growing awareness that comorbidities and multimorbidity impact disease control and quality of life in patients with severe asthma. However, it remains unclear as to how well these conditions are recognised in clinical practice. National severe asthma registries benchmark clinical practice and offer an opportunity to assess how well comorbidities are being considered. <bold>Aim:</bold> We assessed comorbidities collected in 20 European severe asthma registries by studying the Federated Analysis Platform (FAP) of SHARP. <bold>Methods:</bold> The SHARP FAP was used to map comorbidities from 8 European national severe asthma registries in addition to SHARP Central – a harmonised data registry used by 12 countries. <bold>Results:</bold> 48 comorbidities were mapped across the 20 registries. T2-related conditions were best captured with chronic sinusitis and nasal polyposis included in 100% registries, allergic rhinitis 95% and eczema 90%. Several pulmonary (COPD 90%, bronchiectasis 85%, obstructive sleep apnea 75%), extrapulmonary (gastroesophageal reflux 100%, cardiovascular disease 90%) and psychophysiological (depression 85%) were also frequently recorded. Osteoporosis was collected in 85% but other steroid induced pathologies were less well recorded (cataract 70%, diabetes 55%, adrenal insufficiency 40% and glaucoma 25%). <bold>Conclusions:</bold> There is much variability in comorbidity data included in European severe asthma registries. T2 and pulmonary comorbidities are covered well, however the capture of potential steroid induced pathologies is suboptimal, revealing a possible gap in our daily clinical practice which could be improved with harmonisation of the registries in the near future.

Lithuanian University of Health Sciences (LT), Humanitas University (IT), University Hospital Centre Zagreb (HR), University of Liège (BE), St. John's College of Nursing (US), Johannes Gutenberg University Mainz (DE), Université de Montpellier (FR), Leiden University Medical Center (NL), House of Representatives (NL), Ljubljana University Medical Centre (SI), Hospital de Sant Pau (ES), Bispebjerg Hospital (DK), Hospitais da Universidade de Coimbra (PT), Medisch Centrum Leeuwarden (NL), Karolinska Institutet (SE), Centre Hospitalier Universitaire de Montpellier (FR), Chest Diseases Hospital (KW), Riga East University Hospital (LV), Svenska Örtmedicinska Institute (SE), Istanbul University-Cerrahpaşa (TR), Clinica de Pneumologie Iaşi (RO), Medical University of Lodz (PL), Montpellier Business School (FR), Swedish Asthma and Allergy Association (SE), Institute for Pulmonary Diseases of Vojvodina (RS), Surin Hospital (TH), Országos Korányi Tbc és Pulmonológiai Intézet (HU), University of Southampton (GB), University of Tartu (EE), Istanbul University (TR)
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