Association between advanced lung cancer inflammation index and unstable asthma: A population-based study

Abstract <bold>Background:</bold> Asthma exacerbation is associated with obesity and systemic inflammatory diseases, and advanced lung cancer inflammation index (ALI) is a novel biomarker of nutritional inflammation. The purpose of this study was to investigate the potential relationship between ALI and unstable asthma. <bold>Methods:</bold> This cross-sectional study utilized data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Multifactorial logistic regression, subgroup analyses, interaction assessments, smoothed curve fitting, and threshold effect analysis models were conducted to investigate the association between ALI and unstable asthma. <bold>Result:</bold> The study included 1822 subjects with current asthma, and we found a nonlinear positive association between ALI and unstable asthma, with higher levels of ALI significantly associated with an increased risk of asthma exacerbations in fully corrected models. However, the associations were not entirely consistent across subgroups, and in subgroup analyses by Body Mass Index (BMI) and race, unstable asthma and ALI were independently significant in the BMI (25-29.9) interval and the Non-Hispanic White, with interaction results indicating that BMI moderated the relationship between ALI and unstable asthma. Smoothed curve fitting showed an inverted U-shaped relationship between log ALI and unstable asthma in the BMI<25 interval and male individuals, with inflection points at 1.53 and 2.13, respectively. 结论：我们的研究发现ALI与不稳定型哮喘之间存在非线性正相关，这些发现表明ALI可用作哮喘发作的风险评估工具。