Study on the therapeutic effect and mechanism of different intensities of exercise training on alleviating MCT induced pulmonary hypertension in rats

<bold>Objective:</bold> :Exercise training can benefit PH patients (including symptom improvement, improved exercise endurance), but its exact mechanism is still unclear. There is little research on whether exercise training can reduce pulmonary artery pressure, and the impact of different exercise intensities on pulmonary artery pressure. This article intervenes with different exercise intensities in rats with pulmonary arterial hypertension, in order to explore more suitable exercise rehabilitation plans for patients with pulmonary arterial hypertension.<bold>Methods:</bold>Except for the control group, all rats were subcutaneously injected with Monocrotaline (40mg/kg). <bold>Results:</bold>After exercise training, the RVSP of the low-intensity exercise group significantly decreased and could return to normal, with a statistically significant difference (p<0.001); Moderate and high-intensity exercise can partially alleviate RVSP, but the difference is not statistically significant (P>0.05). After exercise training, the RVHI of the low, medium, and high-intensity exercise groups decreased to varying degrees (p<0.0001, P<0.005, P<0.05). The low-intensity exercise group significantly reduced RV/Body Weight% and WT% (P<0.001), while the other groups showed no improvement (P>0.05). HE staining of skeletal muscle in normal control group rats showed that skeletal muscle cells were arranged neatly with no expansion of gaps, which was opposite to the model group. After treatment, different degrees of repair were observed<bold>Conclusion</bold>:Low-intensity exercise training may be safer, more stable, and more effective for patients with pulmonary hypertension.