A perspective on COVID-19 hospitalised patients across Europe: data from the END-COVID CRC

The COVID-19 pandemic has represented a relevant burden on European healthcare systems in the past few years. Differences in the hospitalised population features, treatment regimens and outcomes across European Countries are expected. An international, multicentric, observational, cross-sectional study has been conducted by the END-COVID clinical research collaboration through the creation of a federation of registries enrolling hospitalised COVID-19 patients at local or national level. Data sharing was achieved only through median [IQR] and absolute numbers (%) of relevant variables, with no individual participant data dissemination. 11 registries from 8 different countries enrolling a total of 19,461 patients have been included in the analysis. All patients had a confirmed SARS-CoV-2 infection. The median age ranged between 56 (Romania) and 80 years (Italy), while male patients ranged from 51.2% (Ireland) to 65.7% (Netherlands). The proportion of patients achieving the diagnosis with a PCR nasal swab test ranged between 69.8% (Czech Republic) and 100.0% (Italy, Netherlands, and Ireland). Southern European centres used both systemic antibiotics (56.0% vs 68.3% vs 74.3%, P < 0.0001) and systemic corticosteroids (40.4% vs 61.1% vs 64.4%, P < 0.0001) less frequently than Northern and Eastern European ones. Access to Intensive Care Unit was less common in Southern European centres compared to Northern and Eastern European centres (10.1% vs 21.5% vs 22.7%, P < 0.0001). In-hospital mortality ranged between 5.7% (Spain) and 33.9% (Croatia). We highlighted substantial differences in the population features, treatment regimens and outcomes of COVID-19 hospitalised patients across Europe.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa1511
Primary Topic
Healthcare Systems and Public Health
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article
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article

A perspective on COVID-19 hospitalised patients across Europe: data from the END-COVID CRC

Sara Tomassetti, Raffaele Antonelli Incalzi, Marko Lucijanić, Cormac McCarthy et al.
Healthcare Systems and Public Health
article

A perspective on COVID-19 hospitalised patients across Europe: data from the END-COVID CRC

Sara Tomassetti, Raffaele Antonelli Incalzi, Marko Lucijanić, Cormac McCarthy, Florin Mihaltan, Mattia Nigro, Vladimír Koblížek, Merel E. Hellemons, Rosario Menéndez, James Duncan Chalmers, Philippe Lambin, Claudia Valenzuela, Branislava Milenković, Alessandra Bandera, Stefano Aliberti
article en

Abstract

The COVID-19 pandemic has represented a relevant burden on European healthcare systems in the past few years. Differences in the hospitalised population features, treatment regimens and outcomes across European Countries are expected. An international, multicentric, observational, cross-sectional study has been conducted by the END-COVID clinical research collaboration through the creation of a federation of registries enrolling hospitalised COVID-19 patients at local or national level. Data sharing was achieved only through median [IQR] and absolute numbers (%) of relevant variables, with no individual participant data dissemination. 11 registries from 8 different countries enrolling a total of 19,461 patients have been included in the analysis. All patients had a confirmed SARS-CoV-2 infection. The median age ranged between 56 (Romania) and 80 years (Italy), while male patients ranged from 51.2% (Ireland) to 65.7% (Netherlands). The proportion of patients achieving the diagnosis with a PCR nasal swab test ranged between 69.8% (Czech Republic) and 100.0% (Italy, Netherlands, and Ireland). Southern European centres used both systemic antibiotics (56.0% vs 68.3% vs 74.3%, P < 0.0001) and systemic corticosteroids (40.4% vs 61.1% vs 64.4%, P < 0.0001) less frequently than Northern and Eastern European ones. Access to Intensive Care Unit was less common in Southern European centres compared to Northern and Eastern European centres (10.1% vs 21.5% vs 22.7%, P < 0.0001). In-hospital mortality ranged between 5.7% (Spain) and 33.9% (Croatia). We highlighted substantial differences in the population features, treatment regimens and outcomes of COVID-19 hospitalised patients across Europe.

Humanitas University (IT), University Hospital Centre Zagreb (HR), Università Campus Bio-Medico (IT), Carol Davila University of Medicine and Pharmacy (RO), University of Dundee (GB), Maastricht University Medical Centre (NL), University Hospital Dubrava (HR), Erasmus MC (NL), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Hospital Universitari i Politècnic La Fe (ES), Maastricht University (NL), University of Belgrade (RS), Hospital Clínico Universitario de Valencia (ES), St. Vincent's University Hospital (IE), Azienda Ospedaliero-Universitaria Careggi (IT), Institutul de Pneumoftiziologie "Marius Nasta" (RO), Hospital General Universitario De Valencia (ES), Hospital Universitario de La Princesa (ES), University Hospital Hradec Králové (CZ), IRCCS Humanitas Research Hospital (IT), University of Florence (IT), Erasmus University Rotterdam (NL)
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Healthcare Systems and Public Health
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