Some Novel Series of 3-Alkylidene 3-Phenylthio-3-Chloro Azetidine -2-One Were Synthesized by The Staudinger Ketene-Imine Cycloaddition and Evaluation of Their Biological Activity

Various series of 3-alkylidene 3-Phenylthio-3-Chloro azetidine -2-one(5) synthesized by reaction of 1- (4'-Methoxyphenyl)-3-chloro-3-phenylthio-4,4-diethoxycarbonylazetidin-2-one (4) with thionyl chloride taking MDC as solvent while synthesis of Compound 4 carried out the reaction between phenyl thio acetic acid and N-(4-Methoxyphenyl)-1,1-diethoxycarbonylimine (2) while compound second synthesized by staring material diethyl keto malonate and p-anisidine. these newly synthesized compound were evaluate using different analytical tools These compounds were also evaluated for their anti- inflammatory and analgesic activities.