Effect of ceftriaxone on the glutamate-glutamine cycle and seizure susceptibility of Tg2576 mouse model of Alzheimer's disease
Disruptions to key components of the glutamate-glutamine cycle are observed in models of AD and epilepsy. However, increasing GLT-1 through ceftriaxone treatment did not influence seizure susceptibility in Tg2576 mice, suggesting this is not an effective strategy to lower seizure susceptibility in AD, or a higher dosage is needed.
Authors
- Hattapark Dejakaisaya (ORCID: https://orcid.org/0000-0001-8135-510X)
- Runxuan Lin (ORCID: https://orcid.org/0009-0001-8585-2784)
- Nigel C. Jones (ORCID: https://orcid.org/0000-0002-1080-8439)
- Anna Harutyunyan (ORCID: https://orcid.org/0000-0002-6165-5639)
- Patrick Kwan (ORCID: https://orcid.org/0000-0001-7310-276X)
- Jianxiong Chan (ORCID: https://orcid.org/0000-0002-0352-6935)
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- The Alfred Hospital (AU)
- Chulabhorn Hospital (TH)
- Monash University (AU)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1177/13872877241289053
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80