Regional differences in glucose metabolic decline and tau deposition in the Alzheimer's continuum brain
Our findings suggest that MTR imaging provides insights into AD pathophysiology by simultaneously assessing glucose metabolism and tau deposition. In the early stage of the AD continuum (MCA and PRC), metabolic decline and tau deposition occur independently in different brain regions.
Authors
- Akinori Nakamura (ORCID: https://orcid.org/0000-0002-4259-1297)
- Shizuka Sakuta (ORCID: https://orcid.org/0000-0002-1920-165X)
- Kohei Hanaoka (ORCID: https://orcid.org/0000-0002-0897-2459)
- Kazumasa Saigoh (ORCID: https://orcid.org/0000-0002-0905-5935)
- Atsushi K. Kono (ORCID: https://orcid.org/0000-0002-0963-7433)
- Takashi Kato (ORCID: https://orcid.org/0000-0003-4430-9678)
- Kazunari Ishii (ORCID: https://orcid.org/0000-0001-6601-952X)
- Hayato Kaida (ORCID: https://orcid.org/0000-0003-2440-3579)
- Kazushi Hanada
- Yasuyuki Kojita (ORCID: https://orcid.org/0000-0002-1152-7487)
- Takahiro Yamada (ORCID: https://orcid.org/0000-0001-6314-7008)
- Mamoru Hashimoto
Institutions
- Kindai University Hospital (JP)
- National Center for Geriatrics and Gerontology (JP)
- Kindai University (JP)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1177/13872877241284314
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.65