The funnel effect of reserves prompted by leisure activities across the Alzheimer's disease continuum
This study shows a funnel effect due to gradual reduction of stimulatory activities in the transition from healthy aging to AD. Reserve indices taking into account different types of stimulatory activities allow to capture even smallest residual effects of reserves accumulated over lifespan, until their complete depletion at advanced AD stages. These results may help target tailored interventions during normal and pathological aging.
Authors
- Marta Rodini (ORCID: https://orcid.org/0000-0001-9613-8255)
- Carlo Caltagirone (ORCID: https://orcid.org/0000-0002-0189-4515)
- Martina Assogna (ORCID: https://orcid.org/0000-0002-8588-1112)
- Francesco Di Lorenzo (ORCID: https://orcid.org/0000-0001-9871-229X)
- Giovanni Giulietti (ORCID: https://orcid.org/0000-0001-5073-430X)
- Laura Serra (ORCID: https://orcid.org/0000-0002-2717-1286)
- Lucia Fadda (ORCID: https://orcid.org/0000-0003-0659-9416)
- Giacomo Koch (ORCID: https://orcid.org/0000-0001-6155-9439)
- Sabrina Bonarota (ORCID: https://orcid.org/0009-0008-5514-9108)
- Marco Bozzali (ORCID: https://orcid.org/0000-0002-0568-2026)
- Lucia Mencarelli (ORCID: https://orcid.org/0000-0002-4006-4629)
- Giulia Caruso (ORCID: https://orcid.org/0000-0002-8711-0047)
- Carlotta Di Domenico (ORCID: https://orcid.org/0000-0001-8060-1663)
- Martina Rizzuti
Institutions
- University of Rome Tor Vergata (IT)
- University of Ferrara (IT)
- Marconi University (IT)
- Ospedali Riuniti di Foggia (IT)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1177/13872877241284211
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.31