Molecular docking and dynamics simulation analysis of PDE5 inhibitor candidates for erectile dysfunction treatment.
Among the two ligands tested, Boesenbergin A exhibited superior binding affinity, surpassing even the standard molecule, Sildenafil. This suggests their potential for modulating enzyme activity and potential relevance in erectile dysfunction treatment.
Authors
- Tunahan Ateş (ORCID: https://orcid.org/0000-0001-9087-290X)
- İbrahim Atilla Arıdoğan (ORCID: https://orcid.org/0000-0002-3805-7817)
- Neslihan Akdoğan (ORCID: https://orcid.org/0000-0002-1137-5399)
- Mutlu Değer (ORCID: https://orcid.org/0000-0002-8357-5744)
- İsmail Önder Yılmaz (ORCID: https://orcid.org/0000-0003-2325-177X)
- Rahul Rawat (ORCID: https://orcid.org/0000-0002-6555-7809)
- Tuncel ÖZDEN
- F Uzan
Institutions
- Cukurova University (TR)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.26355/eurrev_202410_36865
- Citations
- 1
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.25