Scratching the surface: Unveiling the complex interplay of itch and psoriasis through contemporary research

The long-lasting presence of itch is an unbearable symptom for people with psoriatic disease, having a profound effect on their quality of life. The itch experience in psoriasis is complex and multifaceted. It is underpinned by neuroimmune interactions, skin barrier dysfunction, and central sensitization pathways. While it has recently been realized that there are neuroimmune interactions in the pathophysiology of itch, tackling chronic itch still proves to be a challenge. The aim of this Perspective Article is two-fold: to assess the novel optimal management strategies for psoriasis-associated itch, while considering the mechanisms of itch in psoriasis and future directions for research.