What can be observed in intervertebral cartilage endplate with aging? An animal model study of excessive axial mechanical loading
Excessive axial loading induced CEPD in the rat tail, primarily characterized by the formation of Schmorl's nodes and a reduction in CEP microporosity in this study. Our modified Ilizarov rat tail compression model, featuring stable and controllable axial loading capabilities, provided an alternative experimental paradigm for further investigation into CEPD.
Authors
- Bei Jiang (ORCID: https://orcid.org/0000-0002-4036-0735)
- Zhouyang Hu (ORCID: https://orcid.org/0009-0002-8989-4903)
- Fan He (ORCID: https://orcid.org/0000-0001-5357-1374)
- Shuaifeng Yan
- Lijun Li (ORCID: https://orcid.org/0000-0002-4595-2908)
- Xinhua Li (ORCID: https://orcid.org/0000-0002-4387-3229)
- Jun Tan (ORCID: https://orcid.org/0000-0001-5206-6640)
Institutions
- Union Hospital (HK)
- Shanghai East Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fmed.2024.1429208
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Guangdong Medical Research Foundation
- National Key Research and Development Program of China