Chronic low-grade inflammation in patients with systemic sclerosis is associated with increased risk for arteriosclerotic cardiovascular disease
Our data indicate that persistent CRP-positivity and thus chronic low-grade inflammation in SSc patients enhance the risk for arteriosclerotic-cardiovascular disease significantly beyond the ASCVD risk observed for our SSc patients without CRP elevations. It seems to be along with a disrupted lipid profile the hallmark of a distinct "inflammatory" subgroup of SSc patients. However, large population-based studies and clinical trials in patients with SSc are needed to validate our findings in a prospective or interventional setting.
Authors
- Reinhard Voll (ORCID: https://orcid.org/0000-0002-5542-9133)
- Stephanie Finzel (ORCID: https://orcid.org/0000-0002-7625-9612)
- Andrew P. Leynes (ORCID: https://orcid.org/0000-0003-0893-3350)
- Marius Keute (ORCID: https://orcid.org/0000-0002-7173-0567)
- Ilona Jandova
- Daria Feldmann
- Ursula Heilmeier (ORCID: https://orcid.org/0000-0003-0664-3413)
- Florian Kollert (ORCID: https://orcid.org/0009-0008-5252-3918)
- Magnus I. Seng
Institutions
- University of Bern (CH)
- University of Freiburg (DE)
- University of California, San Francisco (US)
- University of Basel (CH)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- University Hospital of Basel (CH)
- Krankenhaus Porz am Rhein (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fmed.2024.1446268
- Citations
- 4
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.70