Lipid-lowering drugs, circulating inflammatory factors, and atrial fibrillation: a mediation Mendelian randomization study
Our study provides new insights into the complex interactions among lipid-lowering agents, circulating inflammatory factors and AF, and also identified a potential mediating role of FGF5 in the pathogenesis of AF. Our findings highlight the potential of LPL agonists and targeting specific inflammatory factors for therapeutic intervention in AF, providing promising avenues for future research and clinical strategies for the management and prevention of AF.
Authors
- Yaowu Chen (ORCID: https://orcid.org/0000-0002-6037-0631)
- Huzhi Cai (ORCID: https://orcid.org/0000-0001-9315-8613)
- Qingyang Chen
- Kunpeng Yao (ORCID: https://orcid.org/0000-0002-5839-081X)
- Yang Yang (ORCID: https://orcid.org/0000-0002-1290-6665)
- Xinyu Chen (ORCID: https://orcid.org/0000-0003-3844-6377)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-7936-8777)
- Guangyang Ou
- Zerui Qiu
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fcvm.2024.1446610
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China