DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage
The molecular mechanism of CTD-induced toxicity in mouse liver and L-O2 cells is mainly through DDIT4/mTOR signaling pathway activation, leading to an increase in autophagy and apoptosis levels.
Authors
- Didong Lou (ORCID: https://orcid.org/0000-0003-0059-1587)
- Qin Shi (ORCID: https://orcid.org/0000-0002-9615-0745)
- Fang Peng (ORCID: https://orcid.org/0000-0002-4660-194X)
- Can Zhu
- Yue Pan (ORCID: https://orcid.org/0000-0001-9586-0975)
- Wenchao Tang (ORCID: https://orcid.org/0000-0002-7390-3046)
- Yuanyuan Xiao (ORCID: https://orcid.org/0000-0003-0908-1364)
Institutions
- Guizhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fphar.2024.1480512
- Citations
- 2
- Primary Topic
- Beetle Biology and Toxicology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China