Functional interleukin-4 releasing microparticles impact THP-1 differentiated macrophage phenotype
IL-4 release kinetics fit with the first-order release kinetics model, indicating concentration dependent release. IL-4/HSA encapsulated microparticles modulated THP-1 differentiated macrophages towards pro-immunoregulatory subgroups. This strategy provides a novel approach in drug carrier development for <i>in vitro</i> assessments of macrophage phenotype to inform development of targeted therapies for inflammation and immune modulation.
Authors
- Felicity R. A. J. Rose (ORCID: https://orcid.org/0000-0001-6640-8840)
- Lisa J. White (ORCID: https://orcid.org/0000-0003-0571-999X)
- I‐Ning Lee
- Jasmine Z. Stening
Institutions
- University of Nottingham (GB)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fbioe.2024.1496111
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Wellcome Trust
- International Seafood Sustainability Foundation
- International Foundation for Research in Paraplegia
- UK Regenerative Medicine Platform
- Medical Research Council