Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Primary CAF-containing triple cultures successfully model TAM-like phenotypes <i>ex vivo</i> and allow the assessment of their functional and phenotypic changes in response to treatments following a precision medicine approach.

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Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2024-11-01
DOI
https://doi.org/10.1136/jitc-2024-009494
Citations
18
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
4.33

Funders

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article

Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Johannes Laengle, Markus Fabits, Julijan Kabiljo, Simone Stang et al.
18 citations
Journal for ImmunoTherapy of Cancer
Immune cells in cancer
4.33
article

Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures

Johannes Laengle, Markus Fabits, Julijan Kabiljo, Simone Stang, A Theophil, J Homola, Matthias Farlik, Anna Kusienicka, Andreas Renner, Askin Kulu, Velina S. Atanasova, Michael Bergmann, Oliver Pusch, Anna Chen, Dietmar Herndler‐Brandstetter, Loan Tran, Gerda Egger, Rebecca Zirnbauer, Daphni Ammon, Wolfgang J. Weninger, Henning Walczak, Helmut Dolznig, Nathalie Stürzenbecher
article en
18 citations

Abstract

Primary CAF-containing triple cultures successfully model TAM-like phenotypes <i>ex vivo</i> and allow the assessment of their functional and phenotypic changes in response to treatments following a precision medicine approach.

Journal for ImmunoTherapy of CancerVol. 12(11)
University of Cologne (DE), Comprehensive Cancer Center Vienna (AT), Ludwig Boltzmann Institute Applied Diagnostics (AT), CRUK Lung Cancer Centre of Excellence (GB), University College London (GB), Medical University of Vienna (AT)
Vienna Science and Technology Fund, Österreichischen Akademie der Wissenschaften, Austrian Science Fund, Universität Wien, Österreichische Forschungsförderungsgesellschaft, Medizinische Universität Wien
Good health and well-being
Openalex Percentile: Top 5%
Immune cells in cancer
4.33
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