Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures
Primary CAF-containing triple cultures successfully model TAM-like phenotypes <i>ex vivo</i> and allow the assessment of their functional and phenotypic changes in response to treatments following a precision medicine approach.
Authors
- Johannes Laengle (ORCID: https://orcid.org/0000-0003-4771-1398)
- Markus Fabits (ORCID: https://orcid.org/0000-0001-5582-9615)
- Julijan Kabiljo (ORCID: https://orcid.org/0000-0002-6778-6648)
- Simone Stang (ORCID: https://orcid.org/0009-0007-7075-4149)
- A Theophil
- J Homola
- Matthias Farlik (ORCID: https://orcid.org/0000-0003-0698-2992)
- Anna Kusienicka (ORCID: https://orcid.org/0000-0003-0933-2610)
- Andreas Renner (ORCID: https://orcid.org/0000-0002-1414-5433)
- Askin Kulu
- Velina S. Atanasova (ORCID: https://orcid.org/0000-0002-2294-5473)
- Michael Bergmann (ORCID: https://orcid.org/0000-0001-8529-1166)
- Oliver Pusch (ORCID: https://orcid.org/0000-0001-7166-2800)
- Anna Chen (ORCID: https://orcid.org/0000-0002-5946-6572)
- Dietmar Herndler‐Brandstetter (ORCID: https://orcid.org/0000-0003-0987-0208)
- Loan Tran
- Gerda Egger (ORCID: https://orcid.org/0000-0003-2489-155X)
- Rebecca Zirnbauer (ORCID: https://orcid.org/0000-0002-3921-4001)
- Daphni Ammon (ORCID: https://orcid.org/0000-0001-9969-3430)
- Wolfgang J. Weninger (ORCID: https://orcid.org/0000-0003-0575-0073)
- Henning Walczak (ORCID: https://orcid.org/0000-0002-6312-4591)
- Helmut Dolznig (ORCID: https://orcid.org/0000-0002-6063-3585)
- Nathalie Stürzenbecher
Institutions
- University of Cologne (DE)
- Comprehensive Cancer Center Vienna (AT)
- Ludwig Boltzmann Institute Applied Diagnostics (AT)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/jitc-2024-009494
- Citations
- 18
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Vienna Science and Technology Fund
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund
- Universität Wien
- Österreichische Forschungsförderungsgesellschaft
- Medizinische Universität Wien