Serum Methotrexate Level Predicts Acute Kidney Injury After High-Dose Methotrexate: A Case Report and Single-Center Experience
Timely measurement of serum methotrexate levels is crucial in managing and preventing AKI in patients undergoing HD-MTX therapy. Based on our findings, we propose a modified HD-MTX treatment protocol to reduce the incidence of AKI. This includes earlier serum methotrexate level monitoring and adjustments in urine alkalization and leucovorin dosing strategies.
Authors
- Chien‐Chih Wu (ORCID: https://orcid.org/0000-0002-9517-2176)
- Kuan‐Yu Hung (ORCID: https://orcid.org/0000-0003-3472-5512)
- Shang‐Ju Wu (ORCID: https://orcid.org/0000-0002-0772-869X)
- Szu‐Yu Pan
- Tai‐Chung Huang (ORCID: https://orcid.org/0000-0002-1625-7295)
- Hsing-Yu Lin
- P. T. Yen
Institutions
- National Taiwan University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- International Journal of Nephrology and Renovascular Disease
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/ijnrd.s487368
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- National Taiwan University Hospital
- National Taiwan University