Long-term hypoxia modulates depolarization activation of BKCa currents in fetal sheep middle cerebral arterial myocytes
Overall, LTH attenuates Ca<sup>2+</sup> signaling while increasing the coupling of Ca<sup>2+</sup> sparks to BK<sub>Ca</sub> activity; a process that potentially helps maintain oxygen delivery to the developing brain.
Authors
- Sean M. Wilson (ORCID: https://orcid.org/0000-0003-4404-1173)
- Arlin B. Blood (ORCID: https://orcid.org/0000-0002-4803-5021)
- Danielle Wilson
- Michelle Chan (ORCID: https://orcid.org/0000-0001-6037-7051)
- Jośe L. Puglisi (ORCID: https://orcid.org/0000-0003-0241-8446)
- Christopher G. Wilson (ORCID: https://orcid.org/0000-0003-4644-5593)
- Monica Romero
- Xiang‐Qun Hu (ORCID: https://orcid.org/0000-0003-1626-9541)
- Nikitha Nelapudi
- Madison Boskind
- David Mallari
- Eris Albert-Minckler
- Li Zhang (ORCID: https://orcid.org/0000-0002-9386-8938)
Institutions
- Loma Linda University (US)
- California Northstate University (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3389/fphys.2024.1479882
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Directorate for Biological Sciences