Protopine Exerts Neuroprotective Effects on Neonatal Hypoxic-Ischemic Brain Damage in Rats via Activation of the AMPK/PGC1α Pathway
Pro may exert neuroprotective effects on neonatal hypoxic-ischemic brain damage via activation of the AMPK/PGC1α pathway, suggesting that Pro may be a promising therapeutic candidate for HIE, and our study firstly demonstrate the neuro-protective roles of Pro in HIE models.
Authors
- Xiaoling Guo (ORCID: https://orcid.org/0000-0003-3153-6249)
- Zhenlang Lin (ORCID: https://orcid.org/0000-0003-1637-7622)
- Yingying Hu (ORCID: https://orcid.org/0000-0002-5653-8892)
- Jianghu Zhu (ORCID: https://orcid.org/0000-0002-3661-7999)
- L. Chen
- Shangqin Chen (ORCID: https://orcid.org/0000-0003-4917-0521)
- Xiaoyue Tao
- Tingting Chen (ORCID: https://orcid.org/0000-0001-9520-1259)
- Liying Lu
- Mingchu Fang (ORCID: https://orcid.org/0000-0002-1843-3547)
- Mengdan Pang
Institutions
- Washington State University Spokane (US)
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Georgia Highlands College (US)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/dddt.s484969
- Citations
- 4
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.29