Skin rash in metastatic hormone sensitive prostate cancer patients treated with apalutamide: a retrospective multicenter study in Korea
In a real-world cohort of Korean patients, skin rash occurred in 36.4% of cases, with a median time to onset of 65.5 days. Grade 3 skin rash developed in 10.3% of cases. While MLR and SIRI were significantly higher in the G2 plus G3 group, these markers cannot be considered reliable predictors due to a low area under the curve (AUC < 0.7) before apalutamide treatment. However, increased levels of PLR, SII, and SIRI could potentially be useful for monitoring for the risk of severe rash development in these patients.
Authors
- Hongzoo Park (ORCID: https://orcid.org/0000-0002-4953-5079)
- Jae Il Chung (ORCID: https://orcid.org/0000-0002-8114-1125)
- Byung Hoon Kim (ORCID: https://orcid.org/0000-0001-5272-6362)
- Tae Gyun Kwon (ORCID: https://orcid.org/0000-0002-4390-0952)
- Jae Young Joung (ORCID: https://orcid.org/0000-0003-2954-1663)
- Kyo Chul Koo (ORCID: https://orcid.org/0000-0001-7303-6256)
- Byung Ha Chung (ORCID: https://orcid.org/0000-0001-9817-3660)
- Taek Won Kang (ORCID: https://orcid.org/0000-0002-7708-819X)
- S.H. Yu
- U‐Syn Ha (ORCID: https://orcid.org/0000-0001-9930-0588)
- Joongwon Choi (ORCID: https://orcid.org/0000-0001-5978-8179)
- Seok Joong Yun (ORCID: https://orcid.org/0000-0001-7737-4746)
- Jong Wook Park (ORCID: https://orcid.org/0000-0001-7310-4028)
- Yun‐Sok Ha (ORCID: https://orcid.org/0000-0003-3732-9814)
- Sung Kyu Hong (ORCID: https://orcid.org/0000-0002-8344-6774)
- Jung Ki Jo (ORCID: https://orcid.org/0000-0002-6080-7493)
- Hwang Gyun Jeon (ORCID: https://orcid.org/0000-0002-5613-8389)
- Seong Il Seo (ORCID: https://orcid.org/0000-0002-9792-7798)
- Hyun Ho Han (ORCID: https://orcid.org/0000-0002-6268-0860)
- Jun Nyung Lee (ORCID: https://orcid.org/0000-0002-6342-9846)
- Chan Ho Lee (ORCID: https://orcid.org/0000-0002-7750-6806)
- Sungchan Park (ORCID: https://orcid.org/0000-0002-2337-983X)
- Won Tae Kim (ORCID: https://orcid.org/0000-0002-7482-4550)
- Jong Wook Kim (ORCID: https://orcid.org/0000-0003-2228-0640)
- Won Ik Seo (ORCID: https://orcid.org/0000-0002-3004-101X)
- Hak Min Lee
- Soo Dong Kim
- Ji Youl Lee
Institutions
- Ulsan College (KR)
- Kangwon National University (KR)
- Yonsei University (KR)
- Korea University Medical Center (KR)
- Samsung Medical Center (KR)
- Seoul National University Bundang Hospital (KR)
- Kyungpook National University (KR)
- University of Ulsan (KR)
- Chonnam National University Hospital (KR)
- Inje University Busan Paik Hospital (KR)
- National Cancer Center (KR)
- Ulsan University Hospital (KR)
- Chung-Ang University Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Chungbuk National University Hospital (KR)
- Hanyang University (KR)
- Dong-A University (KR)
- Keimyung University (KR)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Prostate International
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1016/j.prnil.2024.10.003
- Citations
- 4
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Research Foundation
- Ministry of Education
- National Research Foundation of Korea