A stochastic approach to tumor modeling incorporating macrophages

Macrophages are essential components of the immune system’s response to tumors, engaging in intricate interactions shaped by factors such as tumor type, progression, and the surrounding microenvironment. These dynamic relationships between macrophages and cancer cells have become a focal point of research, as scientists seek innovative ways to harness the immune system, including macrophages, for cancer immunotherapy. In this study, we introduce a novel model that examines the interaction between tumor and macrophage cells. We provide an in-depth analysis of the equilibrium points and their stability, as well as a thorough investigation into the solution properties of the model. Moreover, by incorporating a stochastic approach, we account for inherent randomness and fluctuations within the system, offering a more comprehensive understanding of tumor-immune dynamics. Numerical simulations further validate the model, providing key insights into how stochastic elements may influence tumor progression and immune response.

Authors

Institutions

Publication Details

Journal
Bulletin of Biomathematics
Published
2024-10-31
DOI
https://doi.org/10.59292/bulletinbiomath.2024007
Citations
5
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
1.98
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A stochastic approach to tumor modeling incorporating macrophages

Necati Özdemir, Sümeyra Uçar, Tarık İnci, İlknur Koca
5 citations
Bulletin of Biomathematics
Mathematical Biology Tumor Growth
1.98
article

A stochastic approach to tumor modeling incorporating macrophages

Necati Özdemir, Sümeyra Uçar, Tarık İnci, İlknur Koca
article en
5 citations

Abstract

Macrophages are essential components of the immune system’s response to tumors, engaging in intricate interactions shaped by factors such as tumor type, progression, and the surrounding microenvironment. These dynamic relationships between macrophages and cancer cells have become a focal point of research, as scientists seek innovative ways to harness the immune system, including macrophages, for cancer immunotherapy. In this study, we introduce a novel model that examines the interaction between tumor and macrophage cells. We provide an in-depth analysis of the equilibrium points and their stability, as well as a thorough investigation into the solution properties of the model. Moreover, by incorporating a stochastic approach, we account for inherent randomness and fluctuations within the system, offering a more comprehensive understanding of tumor-immune dynamics. Numerical simulations further validate the model, providing key insights into how stochastic elements may influence tumor progression and immune response.

Bulletin of Biomathematics
Balıkesir University (TR), Ege University (TR), Muğla University (TR)
Openalex Percentile: Top 14%
Mathematical Biology Tumor Growth
1.98
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.