<i>FOXO3</i> Longevity Genotype Mitigates Risk Posed by Hypertension on Incident Coronary Artery Disease in Middle-Aged Men: Kuakini Honolulu Heart Program
The present prospective study found that longevity-associated FOXO3 genotype did not independently affect the risk of CAD in all men. Rather, it was associated with protection against incident CAD in men with hypertension. Hypertensive middle-aged men with FOXO3TT genotype may merit particular attention in CAD prevention programs.
Authors
- Brian J. Morris (ORCID: https://orcid.org/0000-0003-2468-3566)
- Bradley J. Willcox (ORCID: https://orcid.org/0000-0001-9890-3520)
- Kamal Masaki (ORCID: https://orcid.org/0000-0003-1170-3118)
- Timothy A. Donlon (ORCID: https://orcid.org/0000-0001-6545-6533)
- Randi Chen (ORCID: https://orcid.org/0000-0003-3747-7964)
- Kazuma Nakagawa (ORCID: https://orcid.org/0000-0002-8744-8531)
- Richard Allsopp (ORCID: https://orcid.org/0000-0001-7565-5325)
Institutions
- University of Hawaiʻi at Mānoa (US)
- The University of Sydney (AU)
- Kuakini Medical Center (US)
- UNSW Sydney (AU)
- Queen's Medical Center (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/gerona/glae254
- Citations
- 1
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute