Herpetosin A, a nor-cucurbitane triterpenoid with a 5/6/6/5 ring system from <i>Herpetospermum pedunculosum</i>
Two previously undescribed triterpenoids, herpetosin A (<b>1</b>) and herpetosin B (<b>2</b>), together with two known compounds, cucurbitacin B (<b>3</b>) and dihydrocucurbitacin E (<b>4</b>), were isolated from the seeds of <i>Herpetospermum pedunculosum.</i> Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound <b>1</b> featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound <b>4</b> exhibited anti-proliferative effect with IC<sub>50</sub> values of 4.5 ± 0.1 <i>μ</i>M against A549 cells, 8.2 ± 0.5 <i>μ</i>M against MDA-MB-231 cells, and 2.4 ± 0.3 <i>μ</i>M against HepG2 cells, respectively.
Authors
- Xiaozhong Lan (ORCID: https://orcid.org/0000-0002-8657-5790)
- Zhaoyue Dong (ORCID: https://orcid.org/0000-0002-7462-7688)
- Zhihua Liao
- Yingxiong Ma
- Qianyu Chen (ORCID: https://orcid.org/0009-0000-4835-253X)
- Guowei Wang (ORCID: https://orcid.org/0000-0003-0762-9023)
- Bing Xu (ORCID: https://orcid.org/0000-0002-0647-5045)
- Min Chen
Institutions
- Tibet University (CN)
- Southwest University (CN)
- Animal Husbandry and Veterinary Department (IN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1080/14786419.2024.2424399
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China