Synthesis and antimycotic activity of new derivatives of imidazo[1,2-<i>a</i>]pyrimidines
The heterocyclic core of imidazo[1,2-<i>a</i>]pyrimidine was formed in satisfactory yields as a result of the interaction of the readily available 2-aminoimidazole with <i>N</i>-substituted maleimides or <i>N</i>-arylitaconimides. The mechanism of the studied processes was postulated basing on experimental data, HPLC-MS analysis of reaction mixtures, and quantum chemical calculations. Molecular docking results of the obtained imidazo[1,2-<i>a</i>]pyrimidines, when compared with voriconazole, a drug already in clinical use, suggest that they may possess antifungal activity against <i>Candida albicans</i>.
Authors
- Олег Н. Буров (ORCID: https://orcid.org/0000-0002-7704-033X)
- Федор И. Зубков (ORCID: https://orcid.org/0000-0002-0289-0831)
- Daria A. Mangusheva (ORCID: https://orcid.org/0000-0002-2513-9098)
- K. A. Scherbakov (ORCID: https://orcid.org/0000-0003-4411-1530)
- Dmitriy Yu. Vandyshev (ORCID: https://orcid.org/0000-0001-8606-458X)
- Alexander D. Zagrebaev (ORCID: https://orcid.org/0000-0001-5864-8991)
- Khidmet Safarovich Shikhaliev (ORCID: https://orcid.org/0000-0002-6576-0305)
- T. N. Khmelevskaya
- Alexey S. Trenin (ORCID: https://orcid.org/0000-0003-2293-6646)
Institutions
- National Research University Higher School of Economics (RU)
- Peoples' Friendship University of Russia (RU)
- Southern Federal University (RU)
- St Petersburg University (RU)
- Voronezh State Medical Academy named after N.N. Burdenko (RU)
- Gause Institute of New Antibiotics Russian Academy of Medical Sciences (RU)
- Voronezh State University (RU)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3762/bjoc.20.236
- Citations
- 5
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Ministry of Science and Higher Education of the Russian Federation