Molybdenum-Mediated Reductive <i>ortho</i>-Alkylation of Nitroarenes with Alcohols
A molybdenum-mediated reductive <i>ortho</i>-alkylation of nitroarenes with alcohols for the synthesis of <i>ortho</i>-alkylated anilines has been developed. Using Mo(CO)<sub>6</sub> as both the reductant and the catalyst, a range of <i>ortho</i>-alkyl-substituted anilines were prepared from nitroarenes and alcohols. Preliminary mechanistic studies indicate that nitroarenes were reduced by Mo(CO)<sub>6</sub> to aniline in the presence of H<sub>2</sub>O, while an oxidized Mo species catalyzed the alkylation portion of this reaction.
Authors
- W. LUO (ORCID: https://orcid.org/0009-0008-3201-2387)
- Jin‐Bao Peng (ORCID: https://orcid.org/0000-0002-0568-7740)
- Wei-Feng Wang (ORCID: https://orcid.org/0000-0002-8564-1709)
- Yuqing Wang (ORCID: https://orcid.org/0000-0002-1691-8161)
- Ying Tang (ORCID: https://orcid.org/0000-0002-3931-5734)
Institutions
- Wuyi University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1021/acs.orglett.4c03778
- Citations
- 2
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.32
Funders
- Wuyi University