SIGMAR1 Knockdown Enhances Oral Cancer Cell Chemosensitivity to Cisplatin via Decreased PD-L1 Expression
Emerging evidence suggests that aberrant expression levels of Sigma1 (<i>SIGMAR1</i>, also known as sigma-1 receptor) have been implicated in the progression of various diseases, including cancer. However, its significance in oral cancer (OC) has not been thoroughly explored. To advance in this field, the present study aimed to investigate the impact of <i>SIGMAR1</i> knockdown in oral cancer cells. To do so, we included in this study our cohort of human OC samples and OC cell lines, which were utilized for experimental verification through several in vitro assays. Our findings revealed that <i>SIGMAR1</i> overexpression was associated with poor survival rates and positively correlated with <i>PD-L1</i> overexpression in human oral cancer samples. Furthermore, <i>SIGMAR1</i> inhibition led to a decrease in <i>PD-L1</i> expression and sensitized oral cancer cells to cisplatin treatment by enhancing apoptosis. These results suggest that <i>SIGMAR1</i> knockdown may present a promising strategy worthy of further exploration in the management of oral cancer.
Authors
- Cristiana Bernadelli Garcia (ORCID: https://orcid.org/0000-0003-1354-7024)
- Pablo Shimaoka Chagas (ORCID: https://orcid.org/0000-0002-0652-728X)
- Leandro Luongo Matos (ORCID: https://orcid.org/0000-0002-5068-8208)
- Andréia Machado Leopoldino (ORCID: https://orcid.org/0000-0002-8313-4754)
- Évila Lopes Salles (ORCID: https://orcid.org/0000-0001-6956-7409)
- Graziella Ribeiro de Sousa (ORCID: https://orcid.org/0000-0003-1809-8539)
- Luiz Paulo Kowalski (ORCID: https://orcid.org/0000-0002-0481-156X)
- Rodolfo Cabral Marcelino (ORCID: https://orcid.org/0000-0002-5320-3907)
- Lucas Oliveira Sousa (ORCID: https://orcid.org/0000-0002-8234-2746)
- Babak Baban (ORCID: https://orcid.org/0000-0002-3144-2288)
- Gabriel Silva (ORCID: https://orcid.org/0000-0002-5660-9769)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0734-7026)
Institutions
- Universidade de São Paulo (BR)
- Universidade Federal de Alfenas (BR)
- Augusta University (US)
- Hospital Israelita Albert Einstein (BR)
- AC Camargo Hospital (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3390/ijms252211856
- Citations
- 3
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Universidade de São Paulo
- National Institutes of Health
- National Institute of Dental and Craniofacial Research