Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent <i>PIEZO2</i> mRNA m6A modification
We demonstrated a novel epitranscriptomic mechanism through which YTHDF1 recognizes Piezo2 and controls cardiac fibroblast autophagy and fibrosis through m6A-dependent modulation. Our findings provide new insights for the development of preventive measures for cardiac fibrosis.
Authors
- Hui Tao (ORCID: https://orcid.org/0000-0003-3761-8659)
- Ji-Fei Ding
- Bin Tu
- Kai Song (ORCID: https://orcid.org/0000-0001-6792-7159)
- Jingjing Yang (ORCID: https://orcid.org/0000-0002-4191-4138)
- Jian‐Yuan Zhao (ORCID: https://orcid.org/0000-0001-9861-0330)
- Li-Chan Lin
- Yan Shi (ORCID: https://orcid.org/0000-0003-1671-860X)
- Zhenyu Liu
- Zhiyan Liu (ORCID: https://orcid.org/0009-0001-8137-376X)
Institutions
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- XinHua Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/cvr/cvae239
- Citations
- 15
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 4.90
Funders
- National Natural Science Foundation of China
- Anhui Provincial Key Research and Development Plan