PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway
Our findings suggest that PINK1-mediated mitophagy plays a protective role in pressure overload-induced cardiac hypertrophy via inhibiting the mtDNA-cGAS-STING pathway.
Authors
- Dingli Xu
- Qingchun Zeng (ORCID: https://orcid.org/0000-0001-7665-8237)
- Haobin Zhou (ORCID: https://orcid.org/0000-0002-8905-3584)
- Daojing Gan
- Hao Zhang (ORCID: https://orcid.org/0000-0002-2049-3485)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7246-2608)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-7748-5670)
- Tianyu Xu (ORCID: https://orcid.org/0000-0002-2929-6760)
- Zhuang Ma (ORCID: https://orcid.org/0000-0003-0027-0193)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/cvr/cvae238
- Citations
- 42
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 10.10
Funders
- National Natural Science Foundation of China