Manipulation of Lipid Nanocapsules as an Efficient Intranasal Platform for Brain Deposition of Clozapine as an Antipsychotic Drug
These results highlight the potential of IN LNCs<sub>Clo</sub> as a novel drug delivery system, offering improved therapeutic efficacy, reduced systemic side effects, and better patient compliance in the treatment of schizophrenia and potentially other CNS disorders.
Authors
- Mohammed Khaled Bin Break (ORCID: https://orcid.org/0000-0002-6031-4154)
- Ahmed A. Katamesh
- Hadel A. Abo El-Enin (ORCID: https://orcid.org/0000-0003-2030-4231)
- Amr Radwan (ORCID: https://orcid.org/0000-0002-5567-6708)
- Hend Mohamed Abdel‐Bar (ORCID: https://orcid.org/0000-0001-5833-9267)
- Shimaa M. Hassoun (ORCID: https://orcid.org/0000-0002-2412-4345)
- Gehad M. Subaiea (ORCID: https://orcid.org/0000-0001-9212-7786)
Institutions
- University of Sadat City (EG)
- University of Ha'il (SA)
- Academy of Scientific Research and Technology (EG)
- Egyptian Government (EG)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3390/pharmaceutics16111417
- Citations
- 4
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.83