Exploring a tristhione scorpionate ligand as a suitable chelator for the theranostic pair antimony-119 and antimony-117
We have explored the TMe chelator for complexation of radioantimony and devised a rapid chelation protocol suitable for the short half-life of <sup>117</sup>Sb (T<sub>1/2</sub> = 2.8 h). [<sup>1XX</sup>Sb]Sb-TMe (<sup>1XX</sup>Sb = <sup>117</sup>Sb, <sup>118m</sup>Sb, <sup>120m</sup>Sb and <sup>122</sup>Sb) demonstrated a high stability in presence of cysteine, although low stability was observed at pH > 4. We have achieved a production yield of <sup>117</sup>Sb high enough for clinical applications and demonstrated the excellent SPECT-imaging properties of <sup>117</sup>Sb. The results contribute valuable information for the development of suitable chelators for radioantimony and is a step further towards implementation of the antimony theranostic pair in biomedical applications.
Authors
- Lorraine Gaenaelle Gé (ORCID: https://orcid.org/0000-0001-6303-1718)
- Mads Sondrup Møller (ORCID: https://orcid.org/0000-0003-1674-7742)
- Johan Hygum Dam (ORCID: https://orcid.org/0000-0001-6577-7011)
- Catherine Chen
- Helge Thisgaard (ORCID: https://orcid.org/0000-0001-9492-448X)
- Christine J. McKenzie (ORCID: https://orcid.org/0000-0001-5587-0626)
- Niels Langkjær (ORCID: https://orcid.org/0000-0002-8729-937X)
- Vickie McKee (ORCID: https://orcid.org/0000-0002-7780-5814)
- Virginia Cendán Castillo
Institutions
- University of Southern Denmark (DK)
- Odense University Hospital (DK)
- Dublin City University (IE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s41181-024-00297-5
- Citations
- 7
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.83
Funders
- Novo Nordisk Fonden