Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The [email protected] Study
<b>Background/Objectives</b>: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. <b>Methods</b>: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the [email protected] cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. <b>Results</b>: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31-0.87]) and subjects without weight gain at follow-up (0.35 [0.16-0.78]). <b>Conclusions</b>: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients.
Authors
- Alfonso L. Calle‐Pascual (ORCID: https://orcid.org/0000-0002-3628-9323)
- Josep Franch‐Nadal (ORCID: https://orcid.org/0000-0002-5175-1555)
- Gabriel Olveira (ORCID: https://orcid.org/0000-0002-7646-2899)
- Felipe Javier Chaves (ORCID: https://orcid.org/0000-0001-8009-3689)
- Gemma Rojo‐Martínez (ORCID: https://orcid.org/0000-0003-2179-2134)
- Elías Delgado (ORCID: https://orcid.org/0000-0001-6114-9712)
- Sergio Valdés (ORCID: https://orcid.org/0000-0001-8623-4331)
- Viyey Doulatram‐Gamgaram (ORCID: https://orcid.org/0000-0002-0178-0040)
- Ana Lago‐Sampedro (ORCID: https://orcid.org/0000-0002-3072-9981)
- Luís Castaño (ORCID: https://orcid.org/0000-0003-0437-9401)
- Wasima Oualla‐Bachiri (ORCID: https://orcid.org/0000-0002-9760-0883)
- Eva García‐Escobar (ORCID: https://orcid.org/0000-0002-0134-3473)
- Sara García‐Serrano (ORCID: https://orcid.org/0000-0002-9547-9637)
- Cristina Maldonado‐Araque (ORCID: https://orcid.org/0000-0002-3452-3489)
Institutions
- Universidad de Oviedo (ES)
- University of the Basque Country (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Clínico San Carlos (ES)
- BioCruces Health research Institute (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Hospital Regional Universitario de Málaga (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Hospital Universitario Central de Asturias (ES)
- INCLIVA Health Research Institute (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-04
- DOI
- https://doi.org/10.3390/nu16213788
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas