Overexpression of <i>bla</i> <sub>SHV-12</sub> caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant <i>Klebsiella pneumoniae</i>
We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant <i>Klebsiella pneumoniae</i> isolated from a patient who had not been exposed CAZ/AVI. Overexpression of <i>bla</i><sub>SHV-12</sub> caused by tandem gene amplification contributed to CAZ/AVI resistance instead of the carriage of <i>bla</i><sub>KPC-2</sub>. Enhanced genomic surveillance is essential to identify emerging variants.
Authors
- Ming Lu (ORCID: https://orcid.org/0000-0003-1574-9850)
- Juan Yi
- Chao Liu (ORCID: https://orcid.org/0000-0001-5886-4264)
- Ning Shen (ORCID: https://orcid.org/0000-0001-8783-5403)
- Pengcheng Du (ORCID: https://orcid.org/0000-0002-2930-9920)
- Fan Jiang (ORCID: https://orcid.org/0000-0001-9511-8877)
- Chunjing Du
- Ping Yang (ORCID: https://orcid.org/0009-0003-3987-7467)
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1080/22221751.2024.2426481
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.51
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Third Hospital
- Fundamental Research Funds for the Central Universities