Dendritic cell mineralocorticoid receptor controls blood pressure by regulating T helper 17 differentiation: role of the Plcβ1/4–Stat5–NF-κB pathway
Dendritic cell MR plays important roles in the pathogenesis of hypertension by regulating Th17 through Plcβ1/4-Stat5-NF-κB signalling, and blockade of DC MR is beneficial for treating hypertension.
Authors
- Lin‐Juan Du (ORCID: https://orcid.org/0000-0002-1884-5672)
- Bin Zhou (ORCID: https://orcid.org/0000-0002-5486-2285)
- Sheng‐Zhong Duan (ORCID: https://orcid.org/0000-0001-5399-7252)
- Yi-Tong Pan
- Haixia Lü (ORCID: https://orcid.org/0000-0002-9787-1771)
- Da Shang
- Youcun Qian (ORCID: https://orcid.org/0000-0002-2269-888X)
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-6227-024X)
- Xingyu Zhang (ORCID: https://orcid.org/0000-0002-6058-850X)
- Lan Bai (ORCID: https://orcid.org/0000-0002-3190-9765)
- Shiwei Zhu (ORCID: https://orcid.org/0009-0004-0966-6439)
- Chao Bi
- Wen-Zhen Lin (ORCID: https://orcid.org/0000-0002-7517-6364)
- Hui Xiao (ORCID: https://orcid.org/0000-0002-4201-0851)
- Ruogu Li (ORCID: https://orcid.org/0000-0002-0608-524X)
- Hong Zhu (ORCID: https://orcid.org/0000-0001-9815-3934)
- Yongli Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Shanghai Ninth People's Hospital (CN)
- Center for Excellence in Molecular Cell Science (CN)
- National Clinical Research (US)
- Shanghai East Hospital (CN)
- Stomatology Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Huashan Hospital (CN)
- Institute of Infection and Immunity (CA)
- University of Chinese Academy of Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/eurheartj/ehae670
- Citations
- 8
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China