Dual Targeting of CX3CR1 and PARP in Models of High-Grade Serous Ovarian Carcinoma
While the exact mechanisms determining the nature of the PARPis and AZD8797 interaction remain to be uncovered, our data indicate that, in a subset of models, selected PARPis strongly synergize with the inhibition of CX<sub>3</sub>CR1, suggesting a potential therapeutic opportunity.
Authors
- Jia Xie (ORCID: https://orcid.org/0000-0002-7978-1975)
- Maria V. Barbolina (ORCID: https://orcid.org/0000-0003-0827-3508)
Institutions
- University of Illinois Chicago (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-05
- DOI
- https://doi.org/10.3390/cancers16223728
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Illinois at Urbana-Champaign
- University of Illinois at Chicago