Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis (Adv. Sci. 38/2024)
Lysine‐Lactylation In article number 2406333, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan, and co‐workers explore the protein lysine lactylation (Kla) landscape, identifying Kla as a key factor in cancer immunotherapy resistance. The cover illustration depicts a tree resembling human lungs under attack by lactylated proteins crossing the immunotherapy barrier. The authors propose APOC2K70 Ab (Ruyi Jingu Bang) as a potent tool to block this process and enhance sensitivity to immunotherapy. [Image: see text]
Authors
- Xiaoying Qiu (ORCID: https://orcid.org/0000-0002-5585-5220)
- Tingting Feng (ORCID: https://orcid.org/0000-0002-6282-1555)
- Li Xu
- Song Huan (ORCID: https://orcid.org/0000-0002-2444-8542)
- Zelin Cui (ORCID: https://orcid.org/0000-0002-2700-5800)
- Deping Zhao (ORCID: https://orcid.org/0000-0001-5242-4233)
- Lianhui Sun
- Chen Huang (ORCID: https://orcid.org/0000-0002-1840-5765)
- Rui Miao (ORCID: https://orcid.org/0000-0001-5046-6341)
- Jingxuan Xu
- Song Guo Zheng (ORCID: https://orcid.org/0000-0002-5611-4774)
- Yanchun Quan
- Chao Xiao (ORCID: https://orcid.org/0000-0001-7070-3156)
- Guangjian Fan (ORCID: https://orcid.org/0000-0003-0684-1380)
- Hongwei Chen (ORCID: https://orcid.org/0000-0002-9400-6053)
- Ming Liu (ORCID: https://orcid.org/0000-0002-4770-4449)
- Yuan Zhang
- Yupeng Wang (ORCID: https://orcid.org/0000-0003-4170-3952)
- Wei Wang (ORCID: https://orcid.org/0000-0002-1614-0759)
- Jian‐Yuan Zhao (ORCID: https://orcid.org/0000-0001-9861-0330)
- Jian Chen (ORCID: https://orcid.org/0000-0002-6740-6043)
- Yi Xu (ORCID: https://orcid.org/0000-0002-4811-9313)
- Ting Zhu (ORCID: https://orcid.org/0009-0007-5530-0210)
- Yifeng Zhu
Publication Details
- Journal
- Advanced Science
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/advs.202470226
- Citations
- 10
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.02