Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin‐K Activity Detection, Revealing Nuclear Activity (Adv. Sci. 38/2024)
Activity‐Based Probes The cover highlights a novel chemical probe that binds a protease, cathepsin K (K), a key player in bone resorption. The probe detects active K in the cell by producing a fluorescent signal. In article number 2401518, Galia Blum and co‐workers describe the development and applications of the probe, also revealing cathepsin K's activity in the nucleoli of multi‐nucleated osteoclast cells. [Image: see text]
Authors
- Jure Loboda (ORCID: https://orcid.org/0000-0002-9601-3484)
- Vito Türk (ORCID: https://orcid.org/0000-0003-0205-6609)
- Galia Blum (ORCID: https://orcid.org/0000-0002-9374-2489)
- Gourab Dey (ORCID: https://orcid.org/0000-0002-9570-5032)
- Ori Wald (ORCID: https://orcid.org/0000-0002-8189-0716)
- Simon Yona (ORCID: https://orcid.org/0000-0002-3984-2008)
- Emmanuelle Merquiol (ORCID: https://orcid.org/0000-0001-5754-498X)
- David Polak (ORCID: https://orcid.org/0000-0003-3211-1330)
- Yael Houri‐Haddad
- Reut Sinai‐Turyansky
- Evalyn Yakobovich
- Nikhila Sridharan
Publication Details
- Journal
- Advanced Science
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/advs.202470230
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00