Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic
Our findings reveal that the allelic frequencies for the <i>CYP2C8</i> polymorphisms in the Saudi pediatric cohort are substantially elevated compared to those reported in other Asian populations. This suggests Saudis may experience more varied drug responses, especially for medications that undergo metabolism by the CYP2C8 enzyme, like ibuprofen.
Authors
- Amina M. Bagher (ORCID: https://orcid.org/0000-0002-1850-5686)
- Lenah S. Binmahfouz (ORCID: https://orcid.org/0000-0002-5142-0588)
- Rawan H. Hareeri (ORCID: https://orcid.org/0000-0003-3742-7879)
- Sara M. Bagher (ORCID: https://orcid.org/0000-0003-4862-9855)
- Rania A. Aboud
- Noura M. Alkinaidri
- Saja A. Aljilani
Institutions
- King Abdulaziz University (SA)
Publication Details
- Journal
- Drug Metabolism and Personalized Therapy
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1515/dmpt-2024-0015
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00