HES1 revitalizes the functionality of aged adipose-derived stem cells by inhibiting the transcription of STAT1
HES1 acts as an inhibitor of cellular senescence in the aging progression of ADSCs through the modulation of STAT1 expression, suggesting a promising avenue for rejuvenating senescent ADSCs and improving wound healing.
Authors
- Chengcheng Li (ORCID: https://orcid.org/0000-0002-7677-6660)
- Chengqi Yan (ORCID: https://orcid.org/0000-0002-8706-2209)
- Zhenbing Chen (ORCID: https://orcid.org/0000-0003-2828-866X)
- Shuoyuan Liu (ORCID: https://orcid.org/0009-0003-4426-0103)
- Sen Ren (ORCID: https://orcid.org/0000-0002-3674-885X)
- Guoyong Jiang (ORCID: https://orcid.org/0000-0002-8844-6837)
- Jiahe Guo (ORCID: https://orcid.org/0009-0008-8828-8155)
- Pengjuan Nie (ORCID: https://orcid.org/0009-0001-9921-9621)
- Jing Chen (ORCID: https://orcid.org/0009-0004-4504-7782)
- Cheng Wang
- Tao Jiang (ORCID: https://orcid.org/0000-0001-7927-2321)
- Hewei Xiong
- Yu Kang (ORCID: https://orcid.org/0000-0002-9808-418X)
Institutions
- Union Hospital (HK)
- Wuhan University (CN)
- Wuhan No.1 Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s13287-024-04002-w
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China