Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia
Various in silico analyses explored the impact of damaging SNP on the function, stability, and structure of EGF-like modules containing mucin-like hormone receptor-like2 (EMR2) protein encoded by the ADGRE2 gene. Genotype analysis was performed on collected blood samples, revealing that altered genotype TT of variant rs765071211 (C/T) was associated significantly with CML patients compared to the control. Further in vitro and in vivo analyses suggest that this SNP holds potential for clinical translation.
Authors
- Yasmin Badshah
- Janeen H. Trembley (ORCID: https://orcid.org/0000-0003-3597-2611)
- Fohad Mabood Husain (ORCID: https://orcid.org/0000-0001-6598-4328)
- Sameen Zafar (ORCID: https://orcid.org/0000-0002-1941-7012)
- Humzah Jamshaid (ORCID: https://orcid.org/0000-0002-6728-2888)
- Suhail Razak (ORCID: https://orcid.org/0000-0003-2167-8630)
- Ayesha Afzal (ORCID: https://orcid.org/0000-0003-4069-0512)
- Maria Shabbir (ORCID: https://orcid.org/0000-0002-5685-3059)
- Tayyaba Afsar (ORCID: https://orcid.org/0000-0003-3181-5731)
- Ghulam Murtaza Kamal
Institutions
- University of Minnesota (US)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Saud Medical City (SA)
- King Saud University (SA)
- Minneapolis VA Health Care System (US)
- University of Minnesota Medical Center (US)
- National University of Technology (PK)
- National University of Sciences and Technology (PK)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1186/s12885-024-13108-6
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- King Saud University